Some years after the groundbreaking mini-series Strangers in Paradise Volume 1, a threat from Kathcoo's past comes back to haunt her and it puts all those around her in danger, including Francine. As the threat levels increase, Katchoo must reveal her shadowy past in order to stop the forces that are out to get her. The series lasts for 14 issues and is then restarted a few months later in Strangers in Paradise Volume 3.